The symptoms of infectious mononucleosis(or mono symptoms) are very diverse. In 2 / 3 of patients the disease begins acutely, states:

• a significant increase in temperature,
• headache,
• weakness,
• muscle and joint pain,
• sleep and appetite disorder,
• there may be light chills, alternating with excessive sweating.

From the first days of illness worries throat sore, which is reinforced when swallowing. Simultaneously observed hyperplasia of lymph nodes and labored nasal breathing. Most clearly listed mono symptoms become pronounced in 4-5-fifth day of illness; in the same period is determined by the increase in the size of the liver and spleen and in the blood appear atypical mononuclear cells.

In some cases, may occur subacute onset with prodrome: against the background of general malaise observed low-grade temperature of the body, expressed mild catarrhal changes of the upper respiratory tract.

In some patients the leading complaint is abdominal pain, often in the right iliac region, and sometimes nausea and vomiting, abdominal distention, delayed stool or diarrhea.

The disease can develop silently, with the first symptom of mono that causes the patient to turn to doctor, is lymph nodes enlargement. However, the most characteristic symptoms of infectious mononucleosis are fever and tonsillitis.

The temperature is highly variable and may persist from 1-2 days to 3 weeks or longer. At 1/3 of patients in the early days of body temperature and low-grade clearly increases up to 38 ˚C and above only at the end of the first week of illness. Increased and prolonged febrile is noticed in adults and children. For some patients there is two-and three-wave fever apyrexia with periods of several days. The average duration of fever is 6-10 days.

The typical temperature curve with infectious mononucleosis does not exist. The body temperature reduces lytic, which coincides with the improvement of general condition and with decreasing severity of other symptoms. It should be noted that after the main wave of low-grade fever is often preserved body temperature.

The temperature reaction is combined with other mono symptoms in the first place with changes in the throat. Small congestion in the throat and tonsillar hyperplasia observed in many patients with the first days of illness. Often these changes are combined with a lesion of nasopharynx. Clinically it is manifested by difficult nasal breathing and nasal tinge of speech. Simultaneously, there is considerable swelling of tonsils, which may come into contact with each other. If you could see the back of the throat, you may notice that its edema and congestion with signs of hyperplasia of lymphoid tissue the rear wall of the pharynx can be covered with thick mucus.

3-4 days after onset of the disease in the tonsils of different sizes appear white fur, which is easily removable with a spatula. In some cases, fur can be localized to the posterior wall of the pharynx, the tongue and even the epiglottis. Changes in the throat accompanied by fever. The length of pharynx lesion is 10-15 days; with timely and adequate treatment angina wears off rather fast.

In patients with tonsillectomy the reaction of the pharynx lymphoid tissue is manifested in the form of increased lateral ridges and granules of the posterior wall of the pharynx. Often, there are enlarged lymph nodes but the most pronounced increase in cervical lymph nodes. Enlarged lymph nodes almost never cause pain.

At the same time can be increased and other groups of lymph nodes – axillary, and inguinal cubital. Increased lymph node persists for 1-2 weeks, and sometimes mild lymphadenopathy observed during 1,5-2 months or more.

At 3-4th day of illness increases the liver and spleen. Hepatomegaly accompanied by a feeling of heaviness in the right hypochondrium, weakness, loss of appetite, nausea, sometimes, rarely vomiting. Often observed moderate hyperbilirubinemia, increase of ALT, thymol.