There is no specific treatment in most cases of infectious mononucleosis. Treatment is aimed at mono symptoms relieving. Available antiviral drugs have no effect and may actually prolong the course of disease. Angina develops rarely in connection with infectious mononucleosis and can be treated with penicillin etc. Ampicillin and amoxicillin must not be used for infectious mononucleosis treatment (90% of patients with infectious mononucleosis are suffered from rash when taking these medicines). Patients may also develop allergy to penicillin. Acetaminophen can be administrated while fever and pain. Sleep and rest are very important. Sore throat is getting worse within 5-7 days since the onset of disease and then disappears within 7-10 days. Lymph nodes enlargement is usually resolved while the third week. The feeling of fatigue may persist for months and it follows the acute phase of illness. It is recommended for patients with infectious mononucleosis to avoid various sports during the first 6-8 weeks after illness in order to prevent enlarged spleen trauma. Enlarged spleen can tear and it is very dangerous for person’s life.

Patients may have viral particles in the saliva for 18 months after infection. When mono symptoms persist for more than six months, the disease is often called “chronic” infection. However, laboratory studies usually can not verify Epstein-Barr virus in people with “chronic” infection.